CovidFranceV1, Main, Exploration, bibRecord, 001395

Case report study of the first five COVID-19 patients treated with remdesivir in France.

Identifieur interne : 001395 ( Main/Exploration ); précédent : 001394; suivant : 001396

Case report study of the first five COVID-19 patients treated with remdesivir in France.

Auteurs : Marie Dubert [France] ; Benoit Visseaux [France] ; Valentina Isernia [France] ; Lila Bouadma [France] ; Laurène Deconinck [France] ; Juliette Patrier [France] ; Paul-Henri Wicky [France] ; Diane Le Pluart [France] ; Laura Kramer [France] ; Christophe Rioux [France] ; Quentin Le Hingrat [France] ; Nadhira Houhou-Fidouh [France] ; Yazdan Yazdanpanah [France] ; Jade Ghosn [France] ; Francois-Xavier Lescure [France]

Source :

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2020.

RBID : pubmed:32619764

Descripteurs français

KwdFr :
- AMP (analogues et dérivés), AMP (effets indésirables), AMP (usage thérapeutique), Abstention thérapeutique (MeSH), Adulte (MeSH), Alanine (analogues et dérivés), Alanine (effets indésirables), Alanine (usage thérapeutique), Antiviraux (effets indésirables), Antiviraux (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (physiologie), Charge virale (effets des médicaments et des substances chimiques), Femelle (MeSH), France (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH).
MESH :
- analogues et dérivés : AMP, Alanine.
- effets des médicaments et des substances chimiques : Betacoronavirus, Charge virale.
- effets indésirables : AMP, Alanine, Antiviraux.
- physiologie : Betacoronavirus.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : AMP, Alanine, Antiviraux.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Abstention thérapeutique, Adulte, Femelle, France, Hospitalisation, Humains, Mâle, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Adenosine Monophosphate (adverse effects), Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Alanine (adverse effects), Alanine (analogs & derivatives), Alanine (therapeutic use), Antiviral Agents (adverse effects), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (physiology), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Female (MeSH), France (MeSH), Hospitalization (MeSH), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), Viral Load (drug effects), Withholding Treatment (MeSH).
MESH :
- chemical , adverse effects : Adenosine Monophosphate, Alanine, Antiviral Agents.
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antiviral Agents.
- geographic : France.
- drug effects : Betacoronavirus, Viral Load.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Pandemics, Withholding Treatment.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the virus responsible for the coronavirus disease 2019 (COVID-19) outbreak worldwide. Data on treatment are scare and parallels have been made between SARS-CoV-2 and other coronaviruses. Remdesivir is a broad-spectrum antiviral with efficient in vitro activity against SARS-CoV-2. Evidence of clinical improvement in patients with severe COVID-19 treated with remdesivir is controversial. The aim of this study was to describe the clinical outcomes and virological monitoring of the first five COVID-19 patients admitted to the intensive care unit of Bichat-Claude Bernard University Hospital, Paris, France, for severe pneumonia related to SARS-CoV-2 and treated with remdesivir. Quantitative reverse transcription PCR was used to monitor SARS-CoV-2 in blood plasma and the lower and upper respiratory tract. Among the five patients treated, two needed mechanical ventilation and one needed high-flow cannula oxygen. A significant decrease in SARS-CoV-2 viral load in the upper respiratory tract was observed in most cases, but two patients died with active SARS-CoV-2 replication in the lower respiratory tract. Plasma samples were positive for SARS-CoV-2 in only one patient. Remdesivir was interrupted before the initialy planned duration in four patients, two because of alanine aminotransferase elevations (3 to 5 normal range) and two because of renal failure requiring renal replacement. This case series of five COVID-19 patients requiring intensive care unit treatment for respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients.

DOI: 10.1016/j.ijid.2020.06.093
PubMed: 32619764
PubMed Central: PMC7326458

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Houhou Fidouh, Nadhira" sort="Houhou Fidouh, Nadhira" uniqKey="Houhou Fidouh N" first="Nadhira" last="Houhou-Fidouh">Nadhira Houhou-Fidouh</name>
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<author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
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<author><name sortKey="Ghosn, Jade" sort="Ghosn, Jade" uniqKey="Ghosn J" first="Jade" last="Ghosn">Jade Ghosn</name>
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<author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="Francois-Xavier" last="Lescure">Francois-Xavier Lescure</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Case report study of the first five COVID-19 patients treated with remdesivir in France.</title>
<author><name sortKey="Dubert, Marie" sort="Dubert, Marie" uniqKey="Dubert M" first="Marie" last="Dubert">Marie Dubert</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France. Electronic address: marie.dubert@aphp.fr.</nlm:affiliation>
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<author><name sortKey="Visseaux, Benoit" sort="Visseaux, Benoit" uniqKey="Visseaux B" first="Benoit" last="Visseaux">Benoit Visseaux</name>
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<author><name sortKey="Isernia, Valentina" sort="Isernia, Valentina" uniqKey="Isernia V" first="Valentina" last="Isernia">Valentina Isernia</name>
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<author><name sortKey="Deconinck, Laurene" sort="Deconinck, Laurene" uniqKey="Deconinck L" first="Laurène" last="Deconinck">Laurène Deconinck</name>
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<author><name sortKey="Patrier, Juliette" sort="Patrier, Juliette" uniqKey="Patrier J" first="Juliette" last="Patrier">Juliette Patrier</name>
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<author><name sortKey="Wicky, Paul Henri" sort="Wicky, Paul Henri" uniqKey="Wicky P" first="Paul-Henri" last="Wicky">Paul-Henri Wicky</name>
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<author><name sortKey="Le Pluart, Diane" sort="Le Pluart, Diane" uniqKey="Le Pluart D" first="Diane" last="Le Pluart">Diane Le Pluart</name>
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<author><name sortKey="Kramer, Laura" sort="Kramer, Laura" uniqKey="Kramer L" first="Laura" last="Kramer">Laura Kramer</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Pharmacy Unit, Bichat-Claude Bernard University Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP. Nord, Pharmacy Unit, Bichat-Claude Bernard University Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Rioux, Christophe" sort="Rioux, Christophe" uniqKey="Rioux C" first="Christophe" last="Rioux">Christophe Rioux</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Le Hingrat, Quentin" sort="Le Hingrat, Quentin" uniqKey="Le Hingrat Q" first="Quentin" last="Le Hingrat">Quentin Le Hingrat</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris</wicri:regionArea>
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<author><name sortKey="Houhou Fidouh, Nadhira" sort="Houhou Fidouh, Nadhira" uniqKey="Houhou Fidouh N" first="Nadhira" last="Houhou-Fidouh">Nadhira Houhou-Fidouh</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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<author><name sortKey="Ghosn, Jade" sort="Ghosn, Jade" uniqKey="Ghosn J" first="Jade" last="Ghosn">Jade Ghosn</name>
<affiliation wicri:level="3"><nlm:affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris</wicri:regionArea>
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<author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="Francois-Xavier" last="Lescure">Francois-Xavier Lescure</name>
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<wicri:regionArea>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
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<series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title>
<idno type="eISSN">1878-3511</idno>
<imprint><date when="2020" type="published">2020</date>
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<term>Adenosine Monophosphate (therapeutic use)</term>
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<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
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<term>Alanine (analogs & derivatives)</term>
<term>Alanine (therapeutic use)</term>
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<term>Antiviral Agents (therapeutic use)</term>
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<term>Betacoronavirus (physiology)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (virology)</term>
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<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Viral Load (drug effects)</term>
<term>Withholding Treatment (MeSH)</term>
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<term>AMP (effets indésirables)</term>
<term>AMP (usage thérapeutique)</term>
<term>Abstention thérapeutique (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Alanine (analogues et dérivés)</term>
<term>Alanine (effets indésirables)</term>
<term>Alanine (usage thérapeutique)</term>
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<term>Femelle (MeSH)</term>
<term>France (MeSH)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
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<term>Pandémies (MeSH)</term>
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<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the virus responsible for the coronavirus disease 2019 (COVID-19) outbreak worldwide. Data on treatment are scare and parallels have been made between SARS-CoV-2 and other coronaviruses. Remdesivir is a broad-spectrum antiviral with efficient in vitro activity against SARS-CoV-2. Evidence of clinical improvement in patients with severe COVID-19 treated with remdesivir is controversial. The aim of this study was to describe the clinical outcomes and virological monitoring of the first five COVID-19 patients admitted to the intensive care unit of Bichat-Claude Bernard University Hospital, Paris, France, for severe pneumonia related to SARS-CoV-2 and treated with remdesivir. Quantitative reverse transcription PCR was used to monitor SARS-CoV-2 in blood plasma and the lower and upper respiratory tract. Among the five patients treated, two needed mechanical ventilation and one needed high-flow cannula oxygen. A significant decrease in SARS-CoV-2 viral load in the upper respiratory tract was observed in most cases, but two patients died with active SARS-CoV-2 replication in the lower respiratory tract. Plasma samples were positive for SARS-CoV-2 in only one patient. Remdesivir was interrupted before the initialy planned duration in four patients, two because of alanine aminotransferase elevations (3 to 5 normal range) and two because of renal failure requiring renal replacement. This case series of five COVID-19 patients requiring intensive care unit treatment for respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32619764</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3511</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>98</Volume>
<PubDate><Year>2020</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title>
<ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Case report study of the first five COVID-19 patients treated with remdesivir in France.</ArticleTitle>
<Pagination><MedlinePgn>290-293</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1201-9712(20)30528-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2020.06.093</ELocationID>
<Abstract><AbstractText>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the virus responsible for the coronavirus disease 2019 (COVID-19) outbreak worldwide. Data on treatment are scare and parallels have been made between SARS-CoV-2 and other coronaviruses. Remdesivir is a broad-spectrum antiviral with efficient in vitro activity against SARS-CoV-2. Evidence of clinical improvement in patients with severe COVID-19 treated with remdesivir is controversial. The aim of this study was to describe the clinical outcomes and virological monitoring of the first five COVID-19 patients admitted to the intensive care unit of Bichat-Claude Bernard University Hospital, Paris, France, for severe pneumonia related to SARS-CoV-2 and treated with remdesivir. Quantitative reverse transcription PCR was used to monitor SARS-CoV-2 in blood plasma and the lower and upper respiratory tract. Among the five patients treated, two needed mechanical ventilation and one needed high-flow cannula oxygen. A significant decrease in SARS-CoV-2 viral load in the upper respiratory tract was observed in most cases, but two patients died with active SARS-CoV-2 replication in the lower respiratory tract. Plasma samples were positive for SARS-CoV-2 in only one patient. Remdesivir was interrupted before the initialy planned duration in four patients, two because of alanine aminotransferase elevations (3 to 5 normal range) and two because of renal failure requiring renal replacement. This case series of five COVID-19 patients requiring intensive care unit treatment for respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dubert</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France. Electronic address: marie.dubert@aphp.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Visseaux</LastName>
<ForeName>Benoit</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Isernia</LastName>
<ForeName>Valentina</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouadma</LastName>
<ForeName>Lila</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France; AP-HP. Nord, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deconinck</LastName>
<ForeName>Laurène</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patrier</LastName>
<ForeName>Juliette</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France; AP-HP. Nord, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wicky</LastName>
<ForeName>Paul-Henri</ForeName>
<Initials>PH</Initials>
<AffiliationInfo><Affiliation>University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France; AP-HP. Nord, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Pluart</LastName>
<ForeName>Diane</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kramer</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Pharmacy Unit, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rioux</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Hingrat</LastName>
<ForeName>Quentin</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Houhou-Fidouh</LastName>
<ForeName>Nadhira</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yazdanpanah</LastName>
<ForeName>Yazdan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ghosn</LastName>
<ForeName>Jade</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lescure</LastName>
<ForeName>Francois-Xavier</ForeName>
<Initials>FX</Initials>
<AffiliationInfo><Affiliation>AP-HP. Nord, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France; University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France.</Affiliation>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>06</Month>
<Day>30</Day>
</ArticleDate>
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<MedlineTA>Int J Infect Dis</MedlineTA>
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<ISSNLinking>1201-9712</ISSNLinking>
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<NameOfSubstance UI="C000606551">remdesivir</NameOfSubstance>
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<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
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<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
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<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D028761" MajorTopicYN="N">Withholding Treatment</DescriptorName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antiviral therapy</Keyword>
<Keyword MajorTopicYN="N">Case reports</Keyword>
<Keyword MajorTopicYN="N">Remdesivir</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2 viral load</Keyword>
<Keyword MajorTopicYN="N">Viral pneumonia</Keyword>
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<Month>05</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>06</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32619764</ArticleId>
<ArticleId IdType="pii">S1201-9712(20)30528-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.ijid.2020.06.093</ArticleId>
<ArticleId IdType="pmc">PMC7326458</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Dubert, Marie" sort="Dubert, Marie" uniqKey="Dubert M" first="Marie" last="Dubert">Marie Dubert</name>
</region>
<name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name>
<name sortKey="Deconinck, Laurene" sort="Deconinck, Laurene" uniqKey="Deconinck L" first="Laurène" last="Deconinck">Laurène Deconinck</name>
<name sortKey="Ghosn, Jade" sort="Ghosn, Jade" uniqKey="Ghosn J" first="Jade" last="Ghosn">Jade Ghosn</name>
<name sortKey="Houhou Fidouh, Nadhira" sort="Houhou Fidouh, Nadhira" uniqKey="Houhou Fidouh N" first="Nadhira" last="Houhou-Fidouh">Nadhira Houhou-Fidouh</name>
<name sortKey="Isernia, Valentina" sort="Isernia, Valentina" uniqKey="Isernia V" first="Valentina" last="Isernia">Valentina Isernia</name>
<name sortKey="Kramer, Laura" sort="Kramer, Laura" uniqKey="Kramer L" first="Laura" last="Kramer">Laura Kramer</name>
<name sortKey="Le Hingrat, Quentin" sort="Le Hingrat, Quentin" uniqKey="Le Hingrat Q" first="Quentin" last="Le Hingrat">Quentin Le Hingrat</name>
<name sortKey="Le Pluart, Diane" sort="Le Pluart, Diane" uniqKey="Le Pluart D" first="Diane" last="Le Pluart">Diane Le Pluart</name>
<name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="Francois-Xavier" last="Lescure">Francois-Xavier Lescure</name>
<name sortKey="Patrier, Juliette" sort="Patrier, Juliette" uniqKey="Patrier J" first="Juliette" last="Patrier">Juliette Patrier</name>
<name sortKey="Rioux, Christophe" sort="Rioux, Christophe" uniqKey="Rioux C" first="Christophe" last="Rioux">Christophe Rioux</name>
<name sortKey="Visseaux, Benoit" sort="Visseaux, Benoit" uniqKey="Visseaux B" first="Benoit" last="Visseaux">Benoit Visseaux</name>
<name sortKey="Wicky, Paul Henri" sort="Wicky, Paul Henri" uniqKey="Wicky P" first="Paul-Henri" last="Wicky">Paul-Henri Wicky</name>
<name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Sante
   |area=    CovidFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32619764
   |texte=   Case report study of the first five COVID-19 patients treated with remdesivir in France.
}}

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This area was generated with Dilib version V0.6.37.
Data generation: Tue Oct 6 23:31:36 2020. Site generation: Fri Feb 12 22:48:37 2021

	Serveur d'exploration sur la COVID en France
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID en France

Case report study of the first five COVID-19 patients treated with remdesivir in France.

Case report study of the first five COVID-19 patients treated with remdesivir in France.

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